Interest in the study of vulnerability has experienced impressive growth across various disciplines. To contribute to this major but scattered development in the study of vulnerability, this article argues for a multidisciplinary life-course framework. This framework promotes a systemic and dynamic perspective focused on three complementary research directions: multidimensional, multilevel, and multidirectional. On the basis of this life course perspective, the authors also propose a definition of vulnerability as a dynamic process of stress and resources across various domains of life (i.e., work, family, health, migration, etc.), levels (i.e., person, group, collective), and time (i.e., long-term processes).